Arsenal have a lengthy injury list with Olivier Giroud (ankle), Aaron Ramsey (thigh) and Mesut Ozil (shoulder) out.
Kieran Gibbs (calf) is also missing, while Theo Walcott (shoulder), Tomas Rosicky (calf) and Jack Wilshere (ankle) all face late fitness tests.
Cardiff are without Craig Bellamy because of a knee problem, while Declan John is expected to continue in place of injured left-back Andrew Taylor.
Aron Gunnarsson and Peter Odemwingie will hope to earn recalls.
Preferred line-up (if every player fails fitness test)
Jenkinson – Mertesacker – Koscielny – Sagna
Arteta – Flamini
Gnabry – Cazorla – Podolski